A profound slump in manufacturing and a trade war that has slowed economic growth in China has led to a second round of layoffs at 3M, the Minnesota company that makes Post-it notes as well as industrial coatings and ceramics.

The 1,500 job cuts come on top of the 2,000 jobs the company trimmed less than a year ago.

The latest round represents about 1.5% of 3M’s global workforce, and CEO Michael Roman said the cuts will occur across all business groups and geographies.

“We continued to face softness in certain end markets, namely China, automotive, and electronics, which impacted overall growth,” Roman said in a conference call discussing 3M’s fourth-quarter results with analysts.

Earlier this month, the Institute for Supply Management reported that U.S. manufacturing activity fell to the lowest level in more than a decade. A survey by the association of purchasing managers found that companies are uncertain about trade and are seeing weak demand from abroad.

The manufacturing sector last year was rocked by slower global growth and the escalation of trade tensions between the United States and China. President Donald Trump signed an initial agreement with China this month that may ease some of the drag caused by tariffs and threats of additional import taxes. However, the spread of a new virus in China threatens to hammer the nation’s economy, and possibly others.

3M, a component in the Dow Jones Industrial Average, is also wrestling with the environmental clean-up associated with some of its products, including PFAS. Those chemicals are used in firefighting foam, nonstick pots and pans, water-repellent clothing and many other household and personal items. They are nicknamed “forever chemicals” because they persist in the environment.

Studies have associated certain PFAS chemicals with increased risk of cancer and damage to organs such as the liver and thyroid.

3M booked a pre-tax charge of $214 million in the fourth quarter related to those environmental efforts.

3M Inc., which is based in St. Paul, Minnesota, earned $969 million, or $1.66 per share, in the fourth quarter. Its adjusted profit was $1.95 per share, far from the per-share earnings of $2.10 that industry analysts had expected, according to a survey by Zacks Investment Research expected.

Revenue totaled $8.11 billion, just shy of Wall Street forecasts.

3M also makes virus masks and in response to the spreading coronavirus in China, which has now killed at least 106 people, 3M is rapidly increasing production.

The U.S. government chartered a plane to fly out diplomats from the U.S. Consulate in Wuhan, where the outbreak started, and other Americans. China has cut off access to Wuhan and 16 other cities to prevent people from leaving and spreading the virus further.

“We’re seeing increased demand for our respiratory protection products and we’re ramping up our production worldwide in China, around the world, to meet that demand, Roman said. “At the same time, we’re seeing what everybody else is seeing, that there’s — businesses are shutting down, extending their shutdown beyond Lunar New Year so we’re really watching day-to-day what that’s going to mean for our outlook for China.

Shares of 3M, which have fallen 14% over the past year, ended Tuesday down $10.05, or 5.7%, at $165.58.