Among the available options on the Week 6 Big Ten college football slate, Wisconsin (-14) against Purdue is our best spread bet, while our model suggests betting the total in the Purdue vs. Wisconsin matchup. Find more stats and insights on those and other contests to bet on or include in a parlay in the article below.

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Best Week 6 Big Ten Spread Bets

Pick: Wisconsin -14 vs. Purdue

• Matchup: Purdue Boilermakers at Wisconsin Badgers
• Projected Winner & Margin of Victory: Wisconsin by 25.2 points
• Date/Time: Oct. 5 at 12:00 PM ET
• TV Channel: BTN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Indiana -13.5 vs. Northwestern

• Matchup: Indiana Hoosiers at Northwestern Wildcats
• Projected Winner & Margin of Victory: Indiana by 22.8 points
• Date/Time: Oct. 5 at 3:30 PM ET
• TV Channel: BTN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: UCLA +28 vs. Penn State

• Matchup: UCLA Bruins at Penn State Nittany Lions
• Projected Winner & Margin of Victory: Penn State by 19.3 points
• Date/Time: Oct. 5 at 12:00 PM ET
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Washington -2.5 vs. Michigan

• Matchup: Michigan Wolverines at Washington Huskies
• Projected Winner & Margin of Victory: Washington by 6.1 points
• Date/Time: Oct. 5 at 7:30 PM ET
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Michigan State +24 vs. Oregon

• Matchup: Michigan State Spartans at Oregon Ducks
• Projected Winner & Margin of Victory: Oregon by 21 points
• Date/Time: Oct. 4 at 9:00 PM ET
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Use these spread picks at BetMGM today!

Best Week 6 Big Ten Total Bets

Over 46.5 – Purdue vs. Wisconsin

• Matchup: Purdue Boilermakers at Wisconsin Badgers
• Projected Total: 53.8 points
• Date/Time: Oct. 5 at 12:00 PM ET
• TV Channel: BTN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 44.5 – Iowa vs. Ohio State

• Matchup: Iowa Hawkeyes at Ohio State Buckeyes
• Projected Total: 51.6 points
• Date/Time: Oct. 5 at 3:30 PM ET
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo

Under 51.5 – USC vs. Minnesota

• Matchup: USC Trojans at Minnesota Golden Gophers
• Projected Total: 45.5 points
• Date/Time: Oct. 5 at 7:30 PM ET
• TV Channel: BTN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 41.5 – Indiana vs. Northwestern

• Matchup: Indiana Hoosiers at Northwestern Wildcats
• Projected Total: 44.3 points
• Date/Time: Oct. 5 at 3:30 PM ET
• TV Channel: BTN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 52.5 – Michigan State vs. Oregon

• Matchup: Michigan State Spartans at Oregon Ducks
• Projected Total: 50.7 points
• Date/Time: Oct. 4 at 9:00 PM ET
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Take advantage of our picks and place your bet at BetMGM today!

Week 6 Big Ten Standings

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