There are 16 matchups on the NFL’s Week 17 slate, with the (-) among the best bets versus the spread, according to our projections. For more suggestions, including parlay possibilities, keep reading.

NFL Picks Against the Spread – Week 17

Jump to Matchup:

Pick: Jaguars -1 vs. Titans

• Matchup: Tennessee Titans at Jacksonville Jaguars
• Projected Winner & Margin: Jaguars by 4.1 points (Bet on this game at BetMGM)
• Spread: Jaguars -1
• Time: 1 p.m. ET
• Date: Dec. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Saints -1 vs. Raiders

• Matchup: Las Vegas Raiders at New Orleans Saints
• Projected Winner & Margin: Saints by 6.4 points (Bet on this game at BetMGM)
• Spread: Saints -1
• Time: 1 p.m. ET
• Date: Dec. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Steelers +3 vs. Chiefs

• Matchup: Kansas City Chiefs at Pittsburgh Steelers
• Projected Winner & Margin: Chiefs by 1.8 points (Bet on this game at BetMGM)
• Spread: Chiefs -3
• Time: 1 p.m. ET
• Date: Dec. 25
• TV Channel: Netflix
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Broncos +3 vs. Bengals

• Matchup: Denver Broncos at Cincinnati Bengals
• Projected Winner & Margin: Broncos by 2.7 points (Bet on this game at BetMGM)
• Spread: Bengals -3
• Time: 4:30 p.m. ET
• Date: Dec. 28
• TV Channel: NFL Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Seahawks -3.5 vs. Bears

• Matchup: Seattle Seahawks at Chicago Bears
• Projected Winner & Margin: Seahawks by 4.6 points (Bet on this game at BetMGM)
• Spread: Seahawks -3.5
• Time: 8:15 p.m. ET
• Date: Dec. 26
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Lions -3.5 vs. 49ers

• Matchup: Detroit Lions at San Francisco 49ers
• Projected Winner & Margin: Lions by 13.7 points (Bet on this game at BetMGM)
• Spread: Lions -3.5
• Time: 8:15 p.m. ET
• Date: Dec. 30
• TV Channel: ABC/ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Chargers -4 vs. Patriots

• Matchup: Los Angeles Chargers at New England Patriots
• Projected Winner & Margin: Chargers by 8.8 points (Bet on this game at BetMGM)
• Spread: Chargers -4
• Time: 1 p.m. ET
• Date: Dec. 28
• TV Channel: NFL Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Commanders -4 vs. Falcons

• Matchup: Atlanta Falcons at Washington Commanders
• Projected Winner & Margin: Commanders by 9.2 points (Bet on this game at BetMGM)
• Spread: Commanders -4
• Time: 8:20 p.m. ET
• Date: Dec. 29
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Texans +5.5 vs. Ravens

• Matchup: Baltimore Ravens at Houston Texans
• Projected Winner & Margin: Ravens by 2.9 points (Bet on this game at BetMGM)
• Spread: Ravens -5.5
• Time: 4:30 p.m. ET
• Date: Dec. 25
• TV Channel: Netflix
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Cardinals +6 vs. Rams

• Matchup: Arizona Cardinals at Los Angeles Rams
• Projected Winner & Margin: Rams by 3.5 points (Bet on this game at BetMGM)
• Spread: Rams -6
• Time: 8:15 p.m. ET
• Date: Dec. 28
• TV Channel: NFL Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Browns +6.5 vs. Dolphins

• Matchup: Miami Dolphins at Cleveland Browns
• Projected Winner & Margin: Dolphins by 4.4 points (Bet on this game at BetMGM)
• Spread: Dolphins -6.5
• Time: 4:05 p.m. ET
• Date: Dec. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Colts -7.5 vs. Giants

• Matchup: Indianapolis Colts at New York Giants
• Projected Winner & Margin: Colts by 8.2 points (Bet on this game at BetMGM)
• Spread: Colts -7.5
• Time: 1 p.m. ET
• Date: Dec. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Buccaneers -8 vs. Panthers

• Matchup: Carolina Panthers at Tampa Bay Buccaneers
• Projected Winner & Margin: Buccaneers by 23.9 points (Bet on this game at BetMGM)
• Spread: Buccaneers -8
• Time: 1 p.m. ET
• Date: Dec. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bills -10 vs. Jets

• Matchup: New York Jets at Buffalo Bills
• Projected Winner & Margin: Bills by 19.9 points (Bet on this game at BetMGM)
• Spread: Bills -10
• Time: 1 p.m. ET
• Date: Dec. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

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