ST. CLOUD — Printing giant Quad/Graphics will close its commercial printing operation in St. Cloud in late August, affecting about 280 workers, the company said Wednesday.

The exact last day of production at the 237,000-square-foot plant will be determined later, Quad/Graphics spokeswoman Claire Ho said.

The closing stems from Quad/Graphics’ recent $100 million acquisition of Brown Printing Co. of Waseca. Many of the plants in the Quad/Graphics network are equipped to do the special interest or short-run publications done in St. Cloud, Ho said.

“We are moving forward quickly with integration plans following our recent acquisition of Brown Printing Co.,” Ho said.

Ho said a similar announcement was made Wednesday at a plant in Woodstock, Ill.. All full-time employees with Quad/Graphics will be eligible for separation packages, she said.