The available options on the Week 5 college football schedule include Big Ten teams involved in eight games. As you are putting together your betting ticket or selecting parlay options, our model suggests Michigan State (+23.5) against Ohio State is the best bet on the spread, while wagering on the total in the Nebraska vs. Purdue matchup carries the best value. Find more insights and stats on those and other games in the article below.

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Best Week 5 Big Ten Spread Bets

Pick: Michigan State +23.5 vs. Ohio State

• Matchup: Ohio State Buckeyes at Michigan State Spartans
• Projected Winner & Margin of Victory: Ohio State by 5 points
• Date/Time: Sept. 28 at 7:30 PM ET
• TV Channel: Peacock

Pick: UCLA +24 vs. Oregon

• Matchup: Oregon Ducks at UCLA Bruins
• Projected Winner & Margin of Victory: Oregon by 9.5 points
• Date/Time: Sept. 28 at 11:00 PM ET
• TV Channel: FOX

Pick: Maryland +7 vs. Indiana

• Matchup: Maryland Terrapins at Indiana Hoosiers
• Projected Winner & Margin of Victory: Maryland by 1.6 points
• Date/Time: Sept. 28 at 12:00 PM ET
• TV Channel: BTN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Wisconsin +15.5 vs. USC

• Matchup: Wisconsin Badgers at USC Trojans
• Projected Winner & Margin of Victory: USC by 7.7 points
• Date/Time: Sept. 28 at 3:30 PM ET
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo

Pick: Purdue +10 vs. Nebraska

• Matchup: Nebraska Cornhuskers at Purdue Boilermakers
• Projected Winner & Margin of Victory: Nebraska by 4.5 points
• Date/Time: Sept. 28 at 12:00 PM ET
• TV Channel: Peacock

Use these spread picks at BetMGM today!

Best Week 5 Big Ten Total Bets

Over 47.5 – Nebraska vs. Purdue

• Matchup: Nebraska Cornhuskers at Purdue Boilermakers
• Projected Total: 56.3 points
• Date/Time: Sept. 28 at 12:00 PM ET
• TV Channel: Peacock

Over 35.5 – Minnesota vs. Michigan

• Matchup: Minnesota Golden Gophers at Michigan Wolverines
• Projected Total: 40.5 points
• Date/Time: Sept. 28 at 12:00 PM ET
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 51.5 – Wisconsin vs. USC

• Matchup: Wisconsin Badgers at USC Trojans
• Projected Total: 47.8 points
• Date/Time: Sept. 28 at 3:30 PM ET
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo

Under 53.5 – Maryland vs. Indiana

• Matchup: Maryland Terrapins at Indiana Hoosiers
• Projected Total: 51.2 points
• Date/Time: Sept. 28 at 12:00 PM ET
• TV Channel: BTN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 47.5 – Illinois vs. Penn State

• Matchup: Illinois Fighting Illini at Penn State Nittany Lions
• Projected Total: 49.5 points
• Date/Time: Sept. 28 at 7:30 PM ET
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Take advantage of our picks and place your bet at BetMGM today!

Week 5 Big Ten Standings

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