WIMBLEDON, England  — Walking away from Centre Court, Oracene Price — mother and sometimes-coach to Serena and Venus Williams — shook her head after watching one daughter lose at Wimbledon, then the other.

Undeniably great as she is, even defending champion Serena found it too tough to make a deep run at her first Grand Slam tournament in a year after a series of health scares. And as successful as Venus has been at the All England Club, even she couldn’t muster her best after missing nearly five months with a hip injury.

“I don’t think their layoffs helped their rhythm,” Price said. “They both seemed to be making the same kinds of mistakes. They were hit-and-miss, here and there.”

They’re both headed home after straight-set exits in the fourth round against far-less-accomplished opponents Monday. First, 13-time major champion Serena lost 6-3, 7-6 (6) to ninth-seeded Marion Bartoli on Court 1. Then, less than two hours later and before a Centre Court crowd that included Prince William and his new bride, Kate, five-time Wimbledon champion Venus was beaten 6-2, 6-3 by 32nd-seeded Tsvetana Pironkova.

“Definitely not our best day,” Venus said. “I think we both envisioned seeing this day going a little bit different.”